Vitamin K1 is the most abundant in a western diet, primarily found in leafy green vegetables. This emulates the method David uses to take his NMN; in capsules swallowed with a glass of water. So to get the equivalent dose in soft gels, youd need to take 4. Does short, fast runs. NR and NMN need to be kept cool because they dont have a long shelf life. We know with David he takes 800mg of Metformin at night. Metformin is a prescription drug, and thus needs to be acquired through a doctors prescription, at least in most countries. 1 gram of spermidine in the morning. Resveratrol & NMN doses come via Davids recently released book; For Metformin dosing, David mentions taking 800mg at night in Lifespan podcast, Daily vitamin K2, D3 and aspirin all also mentioned in his book, David has discussed taking a statin in his 2019 Joe Rogan interview (, Mentions taking Coenzyme Q10, Alpha Lipoic Acid and Quercetin in his March 2020 interview with Dave Asprey (, Mentions on Twitter taking omega-3 fish oil daily (. Whilst it wont stay at 115F all night, it should hopefully stay warm enough to ferment and turn into yogurt its a very common method 2) Use a dedicated, NMN is able to do some things in mice studies that NR cant. Calorie restriction, can reverse the decline of NAD+. Yes, David Sinclair is legit. But dried fruit is better than juice, Dr. Katz said, because it preserves the fruit's cellular structure, along with the health assets that provides. Optimal dosage for treating diabetes can be figured out based on testing the effects on fasting and post-meal blood glucose. Typically doctors only prescribe Metformin for blood sugar control issues (type 2 diabetes). Together with Dr. Rhonda Patrick, he is one of the main proponents of wholesome food eating to delay aging. If you remember the hype some years ago around red wine being healthy, part of that was due to it containing resveratrol (allbeit in tiny amounts). Is Carnivory Going to Kill Bitcoin Users? Both compounds can induce gastrointestinal distress, so its common to start off on lower dosages, and gradually increase to the desired amount. For foods rich in these, see table 1 in this research paper. More on that below. He doesnt elaborate any further on specifics of why he takes Coenzyme Q10, but hes potentially referring research that suggests statins can reduce Coenzyme Q10 levels in blood26Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction Deichmann et al. An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol, Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults, Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans, Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance, Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients, Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients, The Effect of Resveratrol Supplementation on CardioMetabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, DoubleBlind Controlled Trial, Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial, Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease, Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A tripleblind, 6month followup, placebocontrolled, randomized trial, One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease, Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue, Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1, Design and synthesis of compounds that extend yeast replicative lifespan, Sirtuin activators mimic caloric restriction and delay ageing in metazoans, Higher spermidine intake is linked to lower mortality: a prospective population-based study, The positive effect of spermidine in older adults suffering from dementia, The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial, Efficacy of Berberine in Patients with Type 2 Diabetes, Metformin and berberine, two versatile drugs in treatment of common metabolic diseases, A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution, Vegetables and Mixed Dishes Are Top Contributors to Phylloquinone Intake in US Adults: Data from the 2011-2012 NHANES, Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease, The relationship between vitamin K and peripheral arterial disease, Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling, Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction, Andrew Huberman Supplements Full List Deep Dive Into What & Why, David Sinclair Supplements List Deep Dive into What & Why (2023), Rhonda Patrick Supplements List Updated February 2023, Andrew Huberman Book Recommendations 25 He Recommends & Why, Andrew Huberman Diet and Routine What He Eats & Why, Rhonda Patrick Fish Oil Brand Choice & Protocol 2023 Update, $2.48/gram ($62 / 25g) - when using 10% off, $1.84/gram ($184/ 100g) - when buying 4 tubs, $1.86/gram ($85 / 45g) - when using 10% off, $2.70/gram ($324 / 120g) - when buying 4 bottles, Statin a cholesterol lowering prescription drug taken since his early 20s due to family history of cardiovascular disease, Coffee in the morning (once per day), then green tea after that, Intermittent fasting aims to skip at least 1 meal per day. (2006)15Sirtuin activators mimic caloric restriction and delay ageing in metazoans Sinclair et al. David Sinclair is not vegetarian. Many prescription drugs are toxic and dangerous, says Dr. Sinclair, who believes that supplements can also play an important role in preventing damage from free radicals and promoting health. Nic Walker Sinclair's reputation as an outstanding scientist comes with some history of making . Dr. Sinclairs work on aging has profoundly impacted our understanding of how aging works and what it means to be old- and, more importantly, how we can live longer, healthier lives without radical life extension technologies. Although Dr. Sinclair says there is no way of knowing for sure if 30 percent is the optimal caloric intake level, he also points out that there are now literally hundreds of experiments in animals showing lifespan extension by calorie restriction., RELATED READING: Dr. David Sinclairs Supplement List for Longevity, Theres a lot of evidence that exercise extends lifespan. The immediate metabolism of fructose does not impact insulin levels. Roughly 84 million . Other Ways To Tackle Aging We see that the daily dose of 1 gram (800 mg) of wheat germ, actually only contains 1 milligram (mg) of spermidine. Though Dr. David A. Sinclair has received numerous awards, he still works hard towards achieving more scientific breakthroughs and gives lectures to promote awareness about nutrition and dietetics. 1. They found a noticeable benefit in the subjects with cognitive impairment which is great news for those in that demographic. Examples of wheat germ derived spermidine brands: Examples of spermidine trihydrochloride brands: With resveratrol and NMN, for example, the only way to consume them in large quantities, is via supplementation. High protein intake is associated with low plasma NAD+ levels in a healthy human cohort . Robb Wolfs Food Matrix Paleo Meal Generator, How to Eat More for Hardgainers (using The Hungry Brain). The function of these pathways is hypothesized to lead to better healthspan outcomes. Molecules that are discovered today will need years of testing before they can even come close to rival the amount of data and patient years accumulated by metformin. 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